August 2008 - Journal of the International Society of Sports Nutrition
We have recently demonstrated that oral intake of glycine propionyl-L-carnitine (GPLC) increases plasma nitrate/nitrite (NOx), a surrogate measure of nitric oxide production. However, these findings were observed at rest, and in previously sedentary subjects.

August 2008 - Nitric Oxide Stimulating Dietary Supplements: Introducing Glycine Propiony-L-Carnitine (GPLC)
Nitric oxide (NO_), initially known as endothelium derived relaxing factor (EDRF), is biosynthesized within the body from L-arginine and oxygen by a variety of nitric oxide synthase enzymes...

August 2008 - Oxidative Stress and Exercise: Role of Glycine Propionyl-L-Carnitine (GPLC)
Oxidative stress occurs when the production of reactive oxygen species (ROS), often referred to as “free radicals”, exceeds antioxidant defense (Halliwell and Cross, 1994; Sies, 1997). The antioxidant system is comprised of both endogenous (within the body) and exogenous (outside of the body) defense mechanisms. Oxidative stress may progress to oxidative damage involving cellular proteins (contractile, structural, and enzymatic), lipids, DNA, and other molecules in ways that might lead to abnormal cellular function....

August 2008 - Glycine Propionyl-L-Carnitine (GPLC) and Exercise Metabolism
TAthletes and fitness enthusiasts are constantly looking for methods to improve exercise performance and to lose additional body fat. In this quest, individuals look towards advanced exercise training methods, dietary strategies, and nutritional supplements. Pertaining to the latter, several products are available, some with a substantial body of evidence in support of their use (e.g., creatine, caffeine), and many more with little to no evidence indicating beneficial effects on either exercise performance or body composition.

July 2008 - White Paper: The Efficacy of Dietary Supplementation for Enhanced Nitric Oxide Sythesis: The Scientific Evidence
?Approximately twenty years ago, it was discovered that a particular factor produced within endothelial tissue specifically relaxes the adjacent smooth muscle of blood vessels thereby allowing vasodilation and increased blood flow to various tissues including skeletal muscle. This factor was initially referred to as endothelium-derived relaxing factor but is now known as nitric oxide. While nitric oxide serves as an important signaling molecule involved in numerous physiological functions (such as improved glucose transport and antioxidant properties) the role of nitric oxide and control of skeletal blood flow is the primary issue generally addressed with various proposed nutritional supplements. The marketing of these products is generally based on the assumptions that increased blood flow to exercising muscles will enable 1) increased levels of work output, and/or 2) increased resistance to fatigue with submaximal levels of work, and/or 3) increased recovery following exercise training.

April 2008 - Glycine Propionyl-L-Carnitine HCL, USP (GlycoCarn^®)
for Human Health and Performance
Dietary supplementation with the naturally occurring nutrient L-carnitine has been extensively studied as an aid to improve fatty acid metabolism and aerobic exercise capacity, to provide antioxidant benefits, and to enhance blood flow to active tissues (e.g., skeletal muscle and heart). While multiple forms of carnitine have been studied and are currently available, Propionyl-L-Carnitine (PLC) has been shown to best support healthy heart and skeletal muscle function. A patented and safe USP dietary form of PLC has been developed which is molecularly bonded to glycine, one of the precursor amino acids to carnitine biosynthesis. This form is known as Glycine Propionyl-LCarnitine (GPLC) or GlycoCarn^®, and is one of the AminoCarnitines^® branded and marketed by Sigma-Tau HealthScience.

July 2007 - Announcing the Newly USP Certified AminoCarnitines^®
Sigma-tau HealthScience is proud to announce the acceptance by the USP Ingredient Verification Program for two key AminoCarnitine^® ingredients -- ArginoCarn^®, brand of Acetyl-L-Carnitine Arginate Dihydrochloride and GlycoCarn^®, brand of Glycine Propionyl-L-Carnitine Hydrochloride.